RSC Medicinal Chemistry

Scope

RSC Medicinal Chemistry publishes significant research in medicinal chemistry and related drug discovery science. Research articles published in RSC Medicinal Chemistry must show a breakthrough or significant advance on previously published work, or bring new thinking or results that will have a strong impact in their field. Examples of areas within the journal's scope are: - Design, synthesis and biological evaluation of novel chemical entities or biotherapeutic modalities. To be suitable for publication these must ex-hibit significant potential as new pharmacological agents, tools, probes or potential drugs. - Modifications of known chemical entities or biotherapeutic modalities that result in a significantly greater understanding of their structure-activity re-lationships, an improvement of their properties or provide other infor-mation of significant value, for example, the identification of a new target or mode of action for a known agent. Routine modifications with minimal or no improvement are not suitable for RSC Medicinal Chemistry. - Novel methodologies and technologies in the broader chemical and bio-logical sciences (for example, enabling synthetic chemistry, chemical bi-ology, -omics sciences, nanoscience) with application to drug discovery, target identification or elucidation of the mechanism of action. Biological studies should present sufficient innovation with respect to the chemistry.